Indication For the treatment of serious infections caused by susceptible strains microorganisms. Pharmacodynamics Cefoxitin is a cephamycin antibiotic often grouped with the second-generation cephalosporins. It is active against a broad range of gram-negative bacteria including anaerobes. The methoxy group in the 7a position provides cefoxitin with a high degree of stability in the presence of beta-lactamases, both penicillinases and cephalosporinases, of gram-negative bacteria. Mechanism of action The bactericidal action of cefoxitin results from inhibition of cell wall synthesis.