About Lisuride Dopamine Agonist, Semisynthetic Ergot Derivative Mechanism of Action of Lisuride Lisuride is a dopamine and serotonin receptor partial agonist. It has a high affinity for the dopamine D2, D3 and D4 receptors, as well as serotonin 5-HT1A[1] and 5-HT2A/C receptors