About Sulphasalazine Composed of 5-aminosalicylic acid and sulfapyridine, Anti-infective (in inflammatory bowel disease),Anti arthritic. Mechanism of Action of Sulphasalazine Sulfasalazine exerts its anti-inflammatory action by inhibiting lipoxygenase enzyme. This will leads to decreased production of pro-inflammatory leukotrienes (LTB4) and 5-hydroxy eicosa tetra enoic acids (HETE) in the intestinal wall. It inhibits the production of inflammatory mediators like interleukin-1, tumor necrosis factor-alpha etc Indications for Sulphasalazine 1. Ulcerative colitis 2. Crohn`s disease 3. Rheumatoid arthritis 4. Diarrhea Interactions for Sulphasalazine Folic acid : Signs of folic deficiency with sulphasalazine. Digoxin : Possibly reduced efficacy of digoxin.