About Dapoxetine Dapoxetine is a short-acting selective serotonin reuptake inhibitor (SSRI) marketed for the treatment of premature ejaculation in men. Mechanism of Action of Dapoxetine The mechanism of action of dapoxetine in premature ejaculation is presumed to be linked to the inhibition of neuronal re-uptake of serotonin and the subsequent potentiation of the neurotransmitter's action at pre- and postsynaptic receptors. Interactions for Dapoxetine 1.SSRIs 2.MAOIs &thioridazine 3.Synergisic action with ketoconazole. Typical Dosage for Dapoxetine Maximum 240 mg in divided doses per day.