About STRONTIUM RANEL Bone metabolism modulator, Antiosteoporotic agent Mechanism of Action of STRONTIUM RANEL Strontium ranelate is an antiosteoporotic agent which both increases bone formation and reduces bone resorption. Strontium ranelate stimulates the calcium sensing receptors and leads to the differentiation of pre-osteoblast to osteoblast which increases the bone formation. Strontium ranelate also stimulates osteoblasts to secrete osteoprotegerin in inhibiting osteoclasts formed from pre-osteoclasts in relation to the RANKL system, which leads to the decrease of bone resorption Indications for STRONTIUM RANEL Postmenopausal Osteoporosis Interactions for STRONTIUM RANEL Food, milk and derivative products, and medicinal products containing calcium may reduce the bioavailability of strontium ranelate May reduce the absorption of oral tetracycline and quinolone antibiotics