JANUMET is an oral prescription medicine that, along with diet and exercise, helps lower blood sugar in adults with type 2 diabetes. JANUMET (JAN-you-met) tablets contain 2 prescription medicines: sitagliptin (JANUVIA�) and metformin. Your doctor will determine whether JANUMET is right for you. JANUMET targets 3 key factors to lower blood sugar: Helps your pancreas make more insulin Helps your body more effectively use the insulin that it makes Helps decrease excess sugar that your liver makes JANUMET: Helps control blood sugar throughout the day, including after meals Is not likely to cause weight gain and low blood sugar (hypoglycemia) by itself JANUMET can lower blood sugar more than metformin alone. JANUMET is a powerful type 2 diabetes medicine that combines 2 prescription medicines, sitagliptin (JANUVIA�) and metformin, and can lower blood sugar more than the most commonly prescribed medicine (metformin).