About Bleomycin A glycopeptide antibiotic Derivative Antineoplastic Mechanism of Action of Bleomycin It causes the fragmentation of DNA, RNA and inhibits the protein synthesis. It also inhibits the incorporation of thymine into DNA strands. Its DNA cleavage depends on oxygen and metal ions. Drug chelate the metal ion producing pseudo enzymes that react with oxygen to produce super oxide and hydroxide free radicals that cleave DNA.In addition, these complexes also mediate lipid peroxidation and oxidation of other cellular molecules Indications for Bleomycin 1. Hodgkins disease 2. Squamous cell carcinoma 3. Testicular cancer 4. Pleurodesis 5. Bone cancer 6. Kaposi`s sarcoma 7. Malignant melanoma 8. Mycosis fungoides 9. Skin cancer 10. Thyroid cancer 11. Verruca vulgaris 12. Bladder cancer 13. Lung cancer 14. Lymphoma 15. Non-Hodgkins disease 16. Cervix cancer 17. Choriocarcinoma 18 Brain tumor 19. Glioma