About Desmopressin Synthetic analogue of natural pituitary hormone 8-arginine vasopressin (ADH), antidiuretic hormone,in diabetes insipidus, Hemostatic Agent, Antihemophilic Agent. Mechanism of Action of Desmopressin The drug exerts it`s antidiuretic action by acting as a selective V2 receptor agonist. The activation of V2 receptor present on basolateral side of cell membrane of collecting duct increases intracellular cyclic AMP formation- which leads to activation of cyclic AMP dependent protein kinase A and phosphorylation of relevant proteins. This phosphorylation promotes exocytosis of "aquaporin-2" water channels containing vesicles (WCVs) through apical membrane and more aqueous channels get inserted in to the apical membrane. Endocytosis and degradation of WCVs is also decreased. The water permeability of collecting duct cells increases in proportion to the population of aquaporin-2 channels in the apical membrane. Continuous V2 receptor stimulation also up regulates aquapori