Medicine Description
About Timolol Nonselective Beta Adrenergic,Blocker,Ophthalmic- Antiglaucoma,antimigraine. Mechanism of Action of Timolol Timolol is a non selective beta blocker. It inhibits the beta receptors (?2) present in the eye such as in the ciliary body epithelium and blood vessels. This will leads to decreased aqueous production and reduced intraocular pressure. Aqueous humor production is activated by ? receptor mediated cyclic AMP phosphokinase pathway. Beta receptor blockers will decreases the intracellular cyclic AMP level and reduces intraocular pressure. Another mechanism is that Timolol decreases the ocular blood flow which decreases ultrafiltration responsible for aqueous production. Indications for Timolol 1. Open angle glaucoma 2. Ocular hypertension Typical Dosage for Timolol Timolol 0.25, and 0.5% eye drops are used. Instill 1 drop in to the affected eye for 1 - 2 times daily.