About Loxoprofen Sodium NSAID, Propionic acid derivative, Antiinflammatory and Antipyretic Property Mechanism of Action of Loxoprofen Sodium Loxoprofen is a non-selective cyclooxygenase inhibitor. It works by reducing the synthesis of prostaglandins from arachidonic acid. It is a prodrug that is rapidly converted to its active metabolite after oral admin. Indications for Loxoprofen Sodium Pain and inflammation associated with musculoskeletal and joint disorders Interactions for Loxoprofen Sodium Possible increased risk of seizures when used with ciprofloxacin and norfloxacin May also increase serum levels of warfarin, methotrexate, lithium salts and sulphonylurea derivatives