About Miconazole An imidazole derivative, Broad spectrum Antifungal. Mechanism of Action of Miconazole Miconazole is fungicidal or fungistatic depending on the drug concentrations. I t inhibits the conversion of Lanosterol to 14 demethyl Lanosterol by inhibiting the cytochromeP450 enzyme 14 alpha demethylase and impair ergosterol synthesis