About Miconazole An imidazole derivative, Broad spectrum Antifungal. Mechanism of Action of Miconazole Miconazole is fungicidal or fungistatic depending on the drug concentrations. I t inhibits the conversion of Lanosterol to 14 demethyl Lanosterol by inhibiting the cytochromeP450 enzyme 14 alpha demethylase and impair ergosterol synthesis Indications for Miconazole 1.Tinea versicolor 2.Vulvovaginal candidiasis 3.Tinea pedis 4.Tinea corporis 5.Tinea cruris 6.Otomycosis 7.Onychomycosis 8.Oral candidiasis 9.Intestinal candidiasis 10.Diaper dermatitis Interactions for Miconazole Benzoyl peroxide: Antibacterial synergism.