About Oxaliplatin Alkylating-like- a diaminocyclohexane Platinum Analog, Antineoplastic. Mechanism of Action of Oxaliplatin Oxaliplatin is a diaminocyclohexane platinum derivative with a broad spectrum of activity. It undergoes rapid non-enzymatic activation with the displacement of the oxalate ring by two chlorines.Chloride is replaced by water and form a positively charged molecule. Oxaliplatin is activated to a bis-aquated species through a number of reactions. The bis-aquated species then reacts with neighbouring guanine residues either on the same or neighbouring strands of DNA. This leads to the cell death. Its cytotoxic effects are more prominent at S phase but it kills the cells at all stages.