About Pentoxifylline A xanthine derivative, Phosphodiesterase inhibitor, Blood viscosity reducing agent. Mechanism of Action of Pentoxifylline The drug exerts its pharmacological action by improving rheological (flow) properties of blood. It improves blood flow to ischaemic areas by increasing capillary blood flow by improving erythrocyte flexibility and reducing blood viscosity. It inhibits phosphodiesterase enzyme. Indications for Pentoxifylline 1.Intermittent claudication 2.Occlusive arterial diseases of limbs 3.Cerebrovascular insufficiency 4.Circulatory disorder due to arteriosclerosis 5.Trophic disorders 6.Acute non haemorrhagic stroke 7.Other chronic occlusive vascular disorders Interactions for Pentoxifylline Warfarin: Bleeding and prolonged prothrombin time in patients receiving pentoxifylline with or without anticoagulants or platelet aggregation inhibitors. PT(Prothrombin Time) should be monitored in patients on warfarin.