About Dopamine Adrenergic Agonist Agent, Phenethylamine derivative, Inotropic agents,Neurotransmitter,Vasopressor. Mechanism of Action of Dopamine The drug exerts it`s pharmacological action by acting as a dopaminergic (both D1&D2) receptor and adrenergic (alpha 1 & ?1) receptor agonist. It dilates renal and mesenteric blood vessels through its D1 receptor action by increasing intracellular cyclic AMP. It increases glomerular filtration rate and Na+ excretion. It is a positive inotropic drug and increases cardiac out put and systolic BP. It also causes coronary vasodilatation. High doses causes increased peripheral resistance and renal vasoconstriction Indications for Dopamine 1. Acute myocardial infarction 2. Cardiogenic Shock 3. Septic Shock 4. Shock due to trauma 5. During cardiac surgery 6. Short term management of chronic heart failure 7. Shock due to renal failure