About Lincomycin It is a Macrolide. Mechanism of Action of Lincomycin It binds to the 50S sub unit of bacterial ribosome and inhibits translocation.ie: they interfere with the transfer of the newly formed peptide chain from the A site to the P site and fails to expose the A site .So that A site is unable to bind with the next aminoacyl tRNA complex. This leads to premature termination of amino acid chain and there by inhibits protein synthesis Indications for Lincomycin 1 Intra abdominal abscess 2.Lung abscess 3.Acne 4.toxoplasmosis 5.Peritonitis 6.Endocarditis 7.Malaria 8.Empyema 9.Skin and soft tissue infection