About Drotaverine Drotaverine is an effective spasmolytic drug. Mechanism of Action of Drotaverine Drotaverine has spasmolytic and vasodilating action. It exerts its action by inhibiting phosphodiesterase enzyme IV. This will leads to a decrease in cyclic AMP level and reduction in calcium ions (Ca2+). The reduction of calcium ions will dilates the unstipped muscles and blood vessels strongly and relieves spasm of smooth muscles. Indications for Drotaverine 1.Smooth muscle spasm 2.Gastrointestinal colic pain 3.Renal colic pain 4.Dysmenorrhoea 5.Uterine neck spasm 6.Post MTP(Medical termination of pregnancy) 7.Post D&C(Dilatation and curettage) 8.Post surgical spasm 9.Irritable bowel syndrome