mechanism: It is thought paracetamol reduces fever by affecting an area of the brain that regulates our body temperature (the hypothalamic heat-regulating center). Paracetamol is about as effective as aspirin or ibuprofen at relieving mild to moderate pain and fever, but unlike aspirin and ibuprofen it has no anti-inflammatory effect. Caffeine is a mild stimulant that helps reduce fatigue. Caffeine is also thought to enhance the painkilling effect of paracetamol. What is it used for? Mild to moderate pain, such as headache, migraine, toothache, sore throat, muscular and rheumatic pain, nerve pain (neuralgia), backache (lumbago) and period pain. Relieving aches, pains, sore throat and fever associated with colds and flu.