About Diclofenac Potassium NSAID, anti-inflammatory ,antipyretic and analgesic. Mechanism of Action of Diclofenac Potassium Diclofenac possess analgesic, anti-inflammatory and antipyretic action. It inhibits the enzyme cyclo-oxygenase and there by inhibits the synthesis of Prostaglandins (((PGs))). It is more potent against cyclo-oxygenase-2 enzyme as compared to other NSAIDs like Indomethacin, Naproxen etc. It reduces intracellular concentrations of free arachidonic acid in leukocyte by altering its release or uptake. Indications for Diclofenac Potassium 1.Rheumatoid arthritis 2.Ankylosing spondylitis 3.Acute gout 4.Joint disorders e.g. inflammatory disease in joints, crystal deposition in the joints 5.Osteoarthritis 6.For the relief of pain and inflammation in dental minor surgery and orthopedic 7.Dysmenorrhoea