About Teicoplanin Glycopeptide antibiotic, Antibiotic similar to vancomycin. Mechanism of Action of Teicoplanin Teicoplanin binds to the terminal dipeptide (amino D alanyl D alanine residue) sequence of peptidoglycan and inhibits the association and cross linking of peptidoglycan and as the result inhibit cell wall synthesis. Indications for Teicoplanin 1. Endocarditis 2. Enterocolitis 3. Methicillin resistant Staphylococcus aureus infection 4. Neutropenic sepsis 5. Bone and joint infection 6. Skin and soft tissue infection 7. Lower respiratory tract infection