About Epirubicin Anthracycline anibiotic, Antineoplastic. Mechanism of Action of Epirubicin This anthracycline drug intercalates DNA strands, which results complex formation it will inhibit DNA & RNA synthesis. It triggers DNA cleavage by inhibiting topoisomerase 2 that leads to cell death. Binding of this drug to the cell membrane and plasma proteins involved this compounds cytotoxic effects. Epirubicin also generates free radicals that cause cell and DNA damage. Indications for Epirubicin 1. Breast cancer 2. Gastric cancer 3. Lung cancer 4. Lymphomas 5. Non Hodgkins disease 6. Ovarian cancer 7. Bladder cancer 8. Pediatric soft tissue sarcoma 9. Soft tissue sarcoma