About Ivabradine Antianginal drug Mechanism of Action of Ivabradine Ivabradine is a heart rate lowering agent that works through selective and specific inhibition of the cardiac pacemaker If current. If current controls the spontaneous diastolic depolarisation in the sinus node and regulate heart rate. Indications for Ivabradine Chronic stable angina pectoris in coronary artery disease patients with normal sinus rhythm Interactions for Ivabradine CYP3A4 inhibitors: Ivabradine may have its serum concentration increased with these inhibitors