About Docetaxel Antimicrotubular, Natural Source (Plant) Derivative, Taxane Derivative, Antineoplastic. Mechanism of Action of Docetaxel This paclitaxel congener binds to beta tubuline and enhances the polymerization of tubuline to stable microtubules. It also interacts directly with microtubules and stabilizing them against depolymerization, inhibits normal recognition of the microtubule network necessary for mitosis. This act at G2/M phase of the cell cycle. Indications for Docetaxel 1. Breast cancer (metastatic) 2. Prostate cancer 3. Lung cancer 4. Stomach cancer 5. Liver cancer 6. Renal cancer 7. Melanoma