About Ticlopidine Thienopyridine derivative, an adenosine diphosphate (ADP) receptor inhibitor, Antiplatelet Agent. Mechanism of Action of Ticlopidine The drug exerts it`s antithrombotic action by interfering with platelet aggregation. It alters surface receptors in platelets and inhibits ADP and fibrinogen induced platelet-fibrinogen and platelet-platelet binding and prevents platelet aggregation. It blocks G-protein coupled P2YAC type of inhibitory purinergic receptors which mediates adenylyl cyclase inhibition by ADP. It prolongs bleeding time. Interactions for Ticlopidine Antacids: Absorption of ticlopidine decreased. Cimetidine: Chronic cimetidine administration results in decreased clearance of ticlopidine. Aspirin: Effect of aspirin on collagen induced platelet aggregation potentiated hence coadministation not recommended. Digoxin: Digoxin levels may be slightly decreased. Theophylline: Elimination half life of theophylline increased significantly.